A P250 SC was my first carry gun. Hid very well for me in a hybrid IWB from White Hat, who at the time was one of the few places that had a mold for it.
As to reliability, you have nothing to worry about. Just make run a box or two of your preferred carry load to function check it, and you'll be good to go. I recently began carrying my full size P320 in 9mm after over 500 trouble free rounds to get familiar with it.