Howdy!
Each mode of carry offers pros and cons - just like anything else. However, if you talk to guys who really know their stuff, they will all immediately rule out any carry position other than "strong side" for general defensive carry.
Once that is settled, it becomes a choice of IWB (inside waist band) or OWB (outside waist band). If you have a lower back injury, IWB can be somewhat less than comfortable. If not, then it is probably (for most folks - certainly not everyone) the best overall method. It gives you a higher level of concealment and a wider range of clothing options. It does take a bit of getting used to, but once you are accustomed to the weight and bulk of having a block of steel in your shorts, you will not even notice it PROVIDING that you have chosen a quality holster AND belt. I will of course recommend my own Max-Con V as my personal first choice, but the Sparks Watch 6 and VM II are both good holsters, as is the Alessi PCH. Matt DelFatti and Josh Bulman both also have excellent (and well deserved) reputations . I also saw one of Eric Larsens Com 3's recently, and it was a very respectable holster as well.
Personally, for any IWB application other than a 5" 1911, I strongly prefer a holster with a closed muzzle - it tends to eliminate "muzzle poke" often experienced with a shorter firearm, and stabilizes the firearm more effectively. If I could not have a Max-Con V , the PCH would be my personal choice of holster.
I don't know if this has helped or not, but (hopefully) it will save you from aquiring the proverbial "holster graveyard" that most new guys inevitably end up having in a box shoved in the back of a closet. Good luck!